BASF develops mosquito net based on new class of insecticide

BASF develops mosquito net based on new class of insecticide

Fiona Haran
www.WTIN.com

 

For Interceptor G2, a long-lasting insecticide-treated mosquito net based on chlorfenapyr. Chlorfenapyr is a new insecticide class for combatting mosquitoes for public health. This is reportedly the first WHO recommendation for a product based on a new insecticide class in more than 30 years.

Mosquitoes are the most dangerous animal on earth – transmitting diseases such as malaria, dengue, Zika and yellow fever

Working with the Innovative Vector Control Consortium (IVCC) and the London School of Hygiene & Tropical Medicine in a collaboration lasting over a decade, BASF’s scientists successfully repurposed chlorfenapyr to be effective on mosquito nets and meet stringent WHO performance thresholds for public health.

Dave Malone, IVCC technical manager, says: “The collaboration with BASF gave us access to an insecticide with a rare combination of attributes: New to public health, effective against resistant mosquitoes, and able to coat polyester netting with a long-lasting formulation.”

A second chlorfenapyr product, an indoor residual spray named Sylando 240SC, is also in the final phases of WHO evaluation, says BASF.

Growing concerns                                                                                                

Around the world, every two minutes a child dies from malaria and there are more than 200 million new cases every year. Malaria is also a major cause of global poverty and its burden is greatest among the most vulnerable.

Long-lasting insecticide-treated mosquito nets (LN) and indoor residual sprays are the cornerstones of malaria prevention, particularly in sub-Saharan Africa. But 60 countries have already reported resistance to at least one class of insecticide used in them. Part of the problem is that there were previously only four WHO-recommended insecticide classes for adult mosquito control; only one of them, the pyrethroid class, was recommended for LNs. Continual use of the same insecticides enabled the highly-adaptable mosquito to develop significant levels of resistance.

Independent trials in Benin, Burkina Faso, Tanzania and the Ivory Coast have proven the efficacy of Interceptor G2 and Sylando 240SC against local insecticide-resistant mosquitoes.

Interceptor G2 from BASF is the first WHO-recommended mosquito net based on non-pyrethroid chemistry to beat insecticide-resistant mosquitoes

Medical entomologist professor Hilary Ranson from the Liverpool School of Tropical Medicine has studied the problem for many years. “We’ve got to take insecticide resistance very seriously,” she says. “In some countries, the local mosquito population has increased its level of resistance 1,000-fold. It has been years since a new class of public health insecticide has appeared on the market. Alternatives are urgently needed.”

Following the WHO recommendation, BASF says it will start preparations to launch Interceptor G2 for malaria prevention. Depending on local registration processes, the new mosquito net is expected to be available to health ministries and aid organisations starting towards the end of this year.

“New resistance management products are desperately needed to prevent mosquito-borne diseases and save lives,” says Egon Weinmueller, head of BASF’s public health business. “This development breakthrough strengthens my personal belief that we really can be the generation to end malaria for good.”

There are more than 200 million cases of malaria each year and almost half a million deaths

About chlorfenapyr

Chlorfenapyr was derived by isolating a toxin from the streptomyces fumanus actinomycete bacterium. It is said to be new to the public health market, but has been used in agriculture and urban pest control, including in homes and food handling areas, worldwide since 1995.

Chlorfenapyr belongs to the pyrrole class of chemistry and has an entirely different mode of action from current WHO-approved insecticides for public health. It works by disrupting the insect’s ability to produce energy. This makes it unlikely to show cross-resistance in mosquitoes that are resistant to currently registered public health insecticides.

 

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